Merge onto I-10 W via the ramp on the Left toward Los Angeles. (Roughly 30 Miles).
merge onto AZ-85 S. via Exit 112 toward I-8/Yuma/San Diego, through the outskirts of Buckeye to Gila Bend. (36.9 Miles) Turn Right onto AZ-85, just before McDonalds, This turn is marked with a sign stating “Mexico” and “SR 85 South”. (40 Miles).
Turn Left onto W. Rasmussen Rd. (Bowling alley on Corner) then Turn Right onto N. AJO Well RD. Turn Left onto E. AJO Hwy/AZ-85/AZ-86. (2.3 miles) Continue South on SR 85 from Ajo. Through the Organ Pipe National Monument to the border at Lukeville, AZ (37.9 Miles).

This is the Last stop prior to entering into Mexico. The convenient strip mall (Gringo Pass) has facilities available if there was anything you need before leaving the U.S.
Once across the border you will continue South into Sonoita, The speed limit here is fairly slow 20km (15 Mph) so be careful. Driving in Mexico is not a problem as long as you drive defensively. About 2 miles from the border you will come to a three way intersection. Stay to the left (towards Caborca). Do not take the direction to San Luis. About 1 block South of there the road will split into a “Y”. “Pharmacia San Luis” will be on your right just before the “Y”. Stay to the right and you will be on the road to Rocky Point. You will pass “Vasquez’s” on your left if you have made the correct turn. There is a traffic light soon after “Vasquez’s” that is easy to miss if you don’t know it is there. Once on the turn off you have about 60 miles to Rocky point. If your driving at night you will see the lights of the Sandy Beach Condo Projects.

From Tucson...

Take W. AJO WAY/AZ-86 W. Continue to follow AZ-86 W. to "Why AZ." (Roughly 118 miles).
You will come to a stop sign at the end of SR 86 “Ajo Way” Turn Left onto S. SONOITA Hwy/AZ-85. Continue to follow AZ-85. through Organ Pipe National Monument to the border at Lukeville, AZ (27 Miles).

This is the Last stop prior to entering into Mexico. The convenient strip mall (Gringo Pass) has facilities available if there was anything you need before leaving the U.S.

Once across the border you will continue South into Sonoita, The speed limit here is fairly slow 20km (15 Mph) so be careful. Driving in Mexico is not a problem as long as you drive defensively. About 2 miles from the border you will come to a three way intersection. Stay to the left (towards Caborca). Do not take the direction to San Luis. About 1 block South of there the road will split into a “Y”. “Pharmacia San Luis” will be on your right just before the “Y”. Stay to the right and you will be on the road to Rocky Point. You will pass “Vasquez’s” on your left if you have made the correct turn. There is a traffic light soon after “Vasquez’s” that is easy to miss if you don’t know it is there. Once on the turn off you have about 60 miles to Rocky point. If your driving at night you will see the lights of the Sandy Beach Condo Projects.

 :

From Yuma there are two main routes available to the Mexican border town of Sonoita where you pick up Mexico Route 8 (MR-8) to Rocky Point. There is an American route and a Mexico route. Both routes are described here. The Mexico Route is about 80 miles shorter than the American Route. Read the directions and comments to decide which is best for you. Merge onto I-8 E. Crossing into Arizona. (17.0 Miles) I-8 E. becomes I-8 (0.7 Miles) Head east on I-8 E. (96.9 Miles) Merge onto I-8 BL E. via EXIT 115 toward AZ-85/PHOENIX/AJO. (1.5 Miles). Continue into Gila Bend and turn left just beyond McDonalds. This turn is marked with a sign stating “Mexico” and “SR 85 South”.
Continue South on SR 85 to Ajo. (40 Miles) Turn LEFT onto W. RASMUSSEN RD. (Bowling alley on Corner) then Turn RIGHT onto N. AJO WELL RD. Turn LEFT onto E. AJO HWY/AZ-85/AZ-86. (2.3 miles) Continue South on SR 85 from Ajo. Through the Organ Pipe National Monument to the border at Lukeville, AZ (37.9 Miles). 

This is the Last stop prior to entering into Mexico. The convenient strip mall AKA (Gringo Pass) has facilities available if there was anything you need before leaving the U.S.
Once across the border you will continue South into Sonoita, The speed limit here is fairly slow 20km (15 Mph) so be careful. Driving in Mexico is not a problem as long as you drive defensively. About 2 miles from the border you will come to a three way intersection. Stay to the left (towards Caborca). Do not take the direction to San Luis. About 1 block South of there the road will split into a “Y”. “Pharmacia San Luis” will be on your right just before the “Y”. Stay to the right and you will be on the road to Rocky Point. You will pass “Vasquez’s” on your left if you have made the correct turn. There is a traffic light soon after “Vasquez’s” that is easy to miss if you don’t know it is there. Once on the turn off you have about 60 miles to Rocky point. If you’re driving at night you will see the lights of the Sandy Beach Condo Projects as you near Puerto Penasco.

Mexico Route...

To take the Mexico route from Yuma proceed south on Arizona SR-95 to the town of San Luis. This is a U.S. border town across from the Mexican town of San Luis Rio Colorado. In San Luis Rio Colorado you pick up Mexico Route 2 (MR-2) and follow that to Sonoita. In Sonoita you pick up MR-8 to Rocky Point (Puerto Penasco).
The author has never been over Mexico Route 2. The route was suggested by a visitor from the San Diego area. Being adventurous souls they took the MR2 route on their trip to Rocky Point and were kind enough to share with us their experience. If you would like to read what they had to say, click here for their own words.

From Southern California.

There are a couple routes available from Southern California. From The San Diego area, follow I-8 East to Yuma and then follow the directions in the "From Yuma" guide.
From L.A. and environs, visitors can take I-10 East to Arizona SR-95 at Quartzite, AZ, then south on Arizona SR-95 to Yuma and then follow the directions in the "From Yuma" guide. Another (longer) way would be to take I-10 East to Buckeye, AZ and turn south on Arizona SR-85. Taking this route you would follow the directions in the "From Phoenix" guide, picking it up where you turn south off of I-10 onto Arizona SR-85.